Get your DNA Origins® Maternal Lineage Report in 4 Easy Steps
- ORDER KIT: Place your order through our online store and we’ll ship your DNA collection kit to your preferred address
- SEND DNA: Use our simple kit to collect a DNA sample and mail samples to the lab
- ANALYZE DNA: Your sample is then analyzed by our federally-certified lab
- GET REPORT: 6-8 weeks after samples arrive at the lab, a detailed personal report is uploaded to your secure online account
There are three possible areas in our mtDNA that can be
- HVRI Testing: this region is
usually sufficient to determine a person's haplogroup
- HVRII and HVRIII Testing: these
two regions can provide more detail if HVSI testing is not sufficient to
determine connection to a haplogroup; it could also further refine a
haplogroup into sub-groups, also called sub-clades
Our testing includes all three areas, giving you the best
coverage of genetic markers for the highest probability of determining your
The Science behind your Maternal Lineage (mtDNA) DNA Test
What makes mitochondrial DNA special? Several
characteristics of mitochondrial DNA distinguish it from the rest of your
cells' DNA, called nuclear DNA.
Results of a maternal lineage test are expressed
in terms of haplogroups—genetic groups of people who share the same set of DNA
markers and can be traced to a certain geographic area that they settled at a
particular point in human history.
Mitochondrial DNA is:
in the cytoplasm, outside the nucleus
passed through the mother. During fertilization, only nuclear DNA from the
sperm enters the cell; thus the father does not make any contribution to
the mitochondrial DNA.
in number. While your nuclear chromosomes are only found in two copies per
cell, one from your mother and one
from your father, mtDNA is found much more abundantly—anywhere
between hundreds to thousands of copies per cell.
and circular. While nuclear DNA is made up of much longer strands of DNA
that are tightly coiled into chromosomes, mitochondrial DNA is found as a
small, circular chromosome.
Mitochondrial DNA codes for proteins that are involved in
cellular respiration. In addition, certain regions of the mtDNA are useful for
ancestry research. These regions are called hypervariable regions (HVR).
HVRs are the site where the most mutations occur in mtDNA.
On average, one letter in the sequence of mtDNA changes every 1,500 years. This
change is then passed on to succeeding generations. The changes in an
individual's mtDNA comprise his or her haplotype—the mitochondrial DNA
profile—that allows scientists to assign a person to his or her haplogroup, a
group of people with similar haplotypes. The haplogroup is associated with a
historical and geographical origin.